CD5 Antikörper (Biotin)

Produktnummer ABIN951347

Der Maus Monoklonal Anti-CD5-Antikörper wurde für FACS validiert. Er ist geeignet, CD5 in Proben von Maus zu detektieren.

Kurzübersicht für CD5 Antikörper (Biotin) (ABIN951347)

Target: CD5

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD5 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: CG16

Produktdetails anti-CD5 Antikörper (Biotin)

Spezifität: This anti-CD5 (Ly 1.2) mAb reacts with T cells from mouse strains expressing the Ly 1.2 phenotype, but does not react with lympholytes from mouse strains expressing the Ly 1.1 phenotype.

Aufreinigung: Protein G Chromatography

Immunogen: C3H.CE - Ly 1.2 : DS from C3H spleen. Fusion Partner: Myeloma SP2/0 - Ag 14 (M5).

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD5

Target: CD5

Andere Bezeichnung: CD5

Hintergrund: CD5 is a 55 kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

Gen-ID: 12507

NCBI Accession: NP_031676

UniProt: P13379